HDGFL2 and malaria: This relationship is defined by multiple factors including antigen turnover and decay rates, affinity characteristics of the antigen capture reagents, whether infections are recent or asymptomatic, and probably also by host factors such as previous exposure to malaria.7–10 Two quantitative multiplex tests, bead-based assay and chemiluminescence-based ELISA, have been described.11,12 The bead-based assay detects Pan aldolase, Pan LDH, and HRP2, whereas the ELISA detects HRP2, Pv LDH, Pan LDH, and C-reactive protein (CRP).