HDGFL3 and malaria: Unfortunately, RDTs recognizing the common epitopes found in HRP2 and HRP3 result in failed diagnosis for clinical P. falciparum infections because of partial or complete deletions of hrp2 and hrp3, and consequently no expression of proteins.4 Characterization of hrp2/3 deletions by polymerase chain reaction (PCR) is time consuming and expensive for larger scale clinical studies.4 Antibodies targeting a conserved epitope in pLDH can detect all human Plasmodium species Pan malaria lactate dehydrogenase (Pan LDH).