However, PPARγ can also increase insulin sensitivity, promote FA absorption by adipocytes and ultimately reduce FA delivery to the liver.28, 29, 34 FXR can maintain bile acid homeostasis and induce acute phase reactive proteins that play important roles in the regulation of lipid metabolism and inhibition of liver inflammation and are generally underexpressed in the liver of NAFLD patients.35, 36 It has been reported that RARα can form a new transcription cascade with PPARγ and reduce the accumulation of TG in the liver37 (Figure 9). Here, NR1H4 is linked to metabolic dysfunction-associated steatotic liver disease.