In examining the role and function of ALKBH8 in human bladder cancer development in vitro, they found that silencing of ALKBH8 through siRNA transfection reduced ROS production via down-regulation of NAD(P)H oxidase-1 (NOX-1) and induced apoptosis through subsequent activation of c-Jun NH(2)-terminal kinase (JNK) and p38 [62]. This evidence concerns the gene NOX1 and urinary bladder cancer.