The distribution of SFRP1-methylated and -unmethylated cases in relation to the tumor type clearly showed that most of the HCC/TLCT samples displayed an enrichment of SFRP1 DNA methylation and that all tumors with a TERT mutation were SFRP1-methylated (Fig. 3e). The gene discussed is SFRP1; the disease is hepatocellular carcinoma.