Stabilizing mutations in the β-catenin (CTNNB1) gene occur with a frequency of up to 37% in HCC and 60–70% in HB and as a consequence, β-catenin accumulates in the nucleus and regulates the expression of target genes (Zucman-Rossi et al. 2015; Bell et al. 2017). The gene discussed is CTNNB1; the disease is hemoglobin measurement.