Other diseases or conditions not associated with urinary abnormalities were also indications for PNKB, including enlarged kidney or kidney dysfunction of unknown cause; IgG4-related diseases; hypocomplementemia; hereditary diseases, such as Fabry disease; and positive tubular injury markers, such as β2 microglobulin (MG), α1 MG, and N-acetyl-β-d glucosaminidase. This evidence concerns the gene HLA-G and immunoglobulin G4-related sclerosing disease.