Since the ribitol effect was most significantly observed in the MCF7 cells, but not in the other cancer cell lines, we further examined expression of LARGE and FKRP in the ribitol-non-responsive H1299, Hela, PC3 and MDA231 cells to assess potential explanation for the observed differential effect of ribitol on glycosylation of α-DG. This evidence concerns the gene LARGE1 and cancer.