Gao et al. reported that TRAF4 is involved in stemness in esophageal squamous cell carcinoma (ESCC) and also validated that has-miR-21-3p directly regulates TRAF4 to promote the proliferation and antiapoptotic ability of ESCC-isolated stem cells36. The gene discussed is TRAF4; the disease is esophageal squamous cell carcinoma.