NR4A2 and Parkinson disease: In fact, several human mutations in the gene encoding for Nurr1 protein, NR4A2, are associated with late-onset familial PD (Le et al., 2003) and the SNPsrs35479735 (insertion/deletion of a G) seems to be a significant risk factor for the development of PD (Liu et al., 2017; Ruiz-Sánchez et al., 2017).