NR4A2 and amyotrophic lateral sclerosis: Furthermore, as neuroinflammation is a characteristic of ALS (see Figs S2 and S3, in agreement with Ilieva et al., 2009; Boido et al., 2014; Anzilotti et al., 2018), and because Nurr1 is reported to have an anti-inflammatory role in astrocytes and microglial cells (Saijo et al., 2009), we investigated its expression in GFAP- and CD68-positive cells.