A glycine-to-arginine substitution at residue 85 (G85R) is one highly studied ALS-associated mutation: G85R-SOD1 is incapable of dimerizing normally and instead misfolds into soluble monomers or oligomers, as well as insoluble aggregates that are toxic to motor neurons (Wang et al., 2009a,b). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.