In humans, mutations in retinaldehyde-binding protein 1 (RLBP1), the gene encoding CRALBP, cause autosomal recessive retinal diseases with phenotypes described as retinitis punctata albescens (RPA), autosomal recessive retinitis pigmentosa (arRP), Bothnia dystrophy, and Newfoundland rod-cone dystrophy (2, –, 9). This evidence concerns the gene RLBP1 and retinitis pigmentosa.