Aberrantly methylated CpGs of classes A and C converged in promoters of 12/102 transcripts (TIGIT, SH3D21, LAX1, LILRB4, CD5, NOD2, POLR3GL, IGFBP4, ZAP70, KSR2, XXYLT1−AS2, and LAG3), highlighting the potential functional relevance of the associated genes in CLL pathogenesis. This evidence concerns the gene IGFBP4 and B-cell chronic lymphocytic leukemia.