Seven out of these miRNAs have been demonstrated to regulate epigenetic key players, and, even more importantly, they regulate genes that have been shown to be recurrently mutated in CLL, namely ARID1A, ASXL1, CHD2, SETD1A, SETD2, and KMT2D. Reasoning that miRNA binding to their target genes results in gene expression changes, we compared expression levels between miRNAs and their target genes in CLL and normal B cells. Here, KMT2D is linked to B-cell chronic lymphocytic leukemia.