It was found that miR-19b-3p level was negatively associated with serum levels of both IL-6 (r = − 0.852, P < 0.001) and TNF-α (r = − 0.761, P < 0.001), revealing that miR-19b-3p might be associated with inflammatory responses for sepsis patients. The gene discussed is IL6; the disease is Sepsis.