Thus, this study reinforce the importance for the genotyping of P. falciparum based on msp-1 and msp-2 in anti-malarial drug efficacy trials, to distinguish between re-infection as recrudescence and emphasize on the importance of implementing msp-1 and msp-2 genotyping in effective malaria management and malaria control strategies in Cameroon and in other endemic areas. This evidence concerns the gene ATAD1 and malaria.