CD274 and schistosomiasis: Accumulating studies also indicate strong PD-L1 expression in squamous tumors of the urinary bladder [17–19], but underlying retrospective cohorts are less suitable to assess the additive value of ICI therapies in SCC disease management: The patient cohort analyzed by Owyong and colleagues comprised mainly Schistosomiasis-associated SCC [17], while the publications by both Reis et al. and Udager et al. lack sufficient SCC sample numbers [18, 19].