miR-372-3p was recently reported to be regulated by lncRNA OSER1-AS1 to positively affect Rab23 expression and ultimately suppress tumour progression in hepatocellular carcinoma (HCC).(Fan et al. 2019) In our study, we mainly explored the functional roles and mechanism of the HULC/miR-372-3p/HMGB1 pathway in osteosarcoma, which has never been identified before. This evidence concerns the gene OSER1 and osteosarcoma.