Rhodamin B is a non-specific inhibitor of GAG synthesis and has been proven to reduce GAG excretion and improve neurological and somatic findings in mice with MPS I. Since inflammation may be involved in the pathophysiology of some MPS I features, trials with anti-inflammatory therapies such as TNF-alpha-antagonists and pentosan polysulfate (PPS) have been attempted. The gene discussed is TNF; the disease is Scheie syndrome.