CDH2 and neoplasm: We found that N-cadherin positivity was significantly associated with distant metastasis and tumor recurrence; 100% of patients with N+ tumors had developed metastasis or disease recurrence as compared with N- tumors that developed distant metastasis or had disease recurrence in 40% and 53% of cases, respectively (p = 0.017 and p = 0.029, respectively; Figure 8B).