NDV introduces two types of PAMPs into the tumor vaccine: (i) cytosolic viral 5’-triphosphate RNA which is recognized by RIG-I receptors [86] and (ii) cell membrane expressed hemagglutinin-neuraminidase (HN) protein which is recognized by NKp46 receptors on NK cells and leads to their activation [87]. This evidence concerns the gene MT-RNR2 and neoplasm.