A study from 2019 analyzed the correlation of different cytokines including IL-6 and irAE during checkpoint inhibitor treatment of various cancers on a two to three weeks basis and identified that the irAE group (n  =  16) had significantly elevated levels of five cytokines (IL-6, CXCL2, CCL20, CXCL8 and CCL23) compared to healthy controls [44]. The gene discussed is CXCL2; the disease is cancer.