Furthermore, DNMT3A-mutated cells are still present in AML patients with long-lasting complete remission, and this is consistent with the idea that epigenetic mutations, in this case DNMT3A mutations, could be preleukemic events, raising the question of whether DNMT3A should be used to monitor MRD [17,50,51]. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.