In The Cancer Genome Atlas (TCGA) project for AML, several genes such as FLT3, NPM1, DNMT3A, CEBPA, IDH1 and IDH2, were found to be recurrently mutated, as well as others never documented before in the pathogenesis of leukemia, including EZH2 [12]. The gene discussed is IDH2; the disease is acute myeloid leukemia.