TNF and Decreased total neutrophil count: The most representative changes in immune function following exposure to hypoxic conditions include decreased CD4+ T cell count; decreased T cell activation and proliferation; lymphocytosis; neutropenia; and inflammatory upregulation of cytokines, such as interleukin (IL)-6, IL-1, C-reactive protein, and tumor necrosis factor (TNF)-α [25,28,29,30,31].