In CKD patients, more information on the relationship between serum Klotho and FGF23 levels and the values of the Wnt ligands, such as Wnt1, Wnt3a, or Wnt10b, could be useful to assess the comorbidities dependent on the Wnt signaling system, such as renal and cardiac fibrosis. This evidence concerns the gene FGF23 and chronic kidney disease.