In a cohort of 23 APS and 64 SLE patients, and 56 healthy donors (HD) we showed that the mRNA levels of Dicer, Drosha, Ago-1, Ago-2 and Xpo-5 were reduced in neutrophils from APS and SLE patients in relation to HD. The gene discussed is AGO2; the disease is autoimmune polyendocrinopathy.