As in the case of aPLs and anti-ds-DNA antibodies, ACPAs isolated from the serum of RA patients induced on healthy neutrophils the downregulation of Dicer, Ago-2 and Xpo-5, as well as a set of microRNAs (miR-let7b, -126, -148a, -29c, -17, -21, -223) regulators of targets involved in cell migration, inflammation and cell survival, which were upregulated in a parallel manner [94]. This evidence concerns the gene AGO2 and rheumatoid arthritis.