They proved in both cells that dovitinib (also known as TKI 1258), which is an anti-FGFR1 antibody, was capable to reduce downstream signalling by a down modulation of pFRS2 and pERK/MAPK as shown by western blotting, and in vivo it reduced tumours in primary breast cancer xenografted HBCx-2 mice [57]. This evidence concerns the gene FGFR1 and breast carcinoma.