FTO and obesity due to melanocortin 4 receptor deficiency: In the Québec Family Study, a variant of the melanocortin‐4 receptor (MC4R) gene was found to be associated with a combined measure of self‐reported sedentary time and physical inactivity28 and in the Framingham Heart study an association of the fat mass and obesity‐associated (FTO) gene with sitting time was reported.29