The three most frequently predicted targets for GRAS/IIG compounds are polyadenylate-binding protein 1 (127 predictions), fatty-acid-binding protein 3 (95 predictions), and sphingosine 1-phosphate receptor Edg-3 (89 predictions), which are implicated in oculopharyngeal muscular dystrophy (Apponi et al., 2010), cardiac fatty acid utilization (Binas et al., 1999), and multiple sclerosis (Choi et al., 2011), respectively. The gene discussed is PABPC1; the disease is multiple sclerosis.