S1PR3 and multiple sclerosis: The three most frequently predicted targets for GRAS/IIG compounds are polyadenylate-binding protein 1 (127 predictions), fatty-acid-binding protein 3 (95 predictions), and sphingosine 1-phosphate receptor Edg-3 (89 predictions), which are implicated in oculopharyngeal muscular dystrophy (Apponi et al., 2010), cardiac fatty acid utilization (Binas et al., 1999), and multiple sclerosis (Choi et al., 2011), respectively.