By contrast, in E5, E6, and E7-expressing cells, we detected lowerlevels of Fox01/FKHR, an important transcriptional regulator of cell proliferation.This finding agrees with previous studies that suggest that Fox01/FKHR plays a vitalrole in inhibiting cervical cancer development by inducing cell-cycle arrest,ultimately suggesting a tumour suppressor function for this protein.58 The gene discussed is FOXO1; the disease is neoplasm.