However, there is controversy about adiponectin role in inflammation since its plasma concentration decreases in some inflammatory diseases, for example in obesity and PCOS, and increases under some other inflammatory conditions – rather than decreased – in classic chronic inflammatory/autoimmune diseases that are unrelated to increased adipose tissue, such as rheumatoid arthritis type 1 diabetes ( 8 ). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.