PTEN can inhibit tumor progression, as it converts phosphatidylinositol-3,4,5-trisphosphate (PIP3) to phosphatidylinositol-4,5-bisphosphate (PIP2) at the cellular membrane; this causes inhibition of PI3K-AKT signaling, hence restraining tumor cell proliferation, migration, and invasion and promoting apoptosis [20,21]. This evidence concerns the gene AKT1 and neoplasm.