FADS1 and aortic stenosis: Mendelian randomization analysis also indicated that genetically elevated FADS1 expression in the liver conferred increased odds of AS (OR per unit increase of normalized expression, 1.31; 95% CI, 1.17-1.48; P = 7.4 × 10−6) and AVC (OR per unit increase of normalized expression, 1.25; 95% CI, 1.02-1.52; P = .03).