In a recent estimated bone mineral density (eBMD) GWAS of 426,824 individuals in the UK Biobank (Morris et al., 2019), novel genetic influences on osteoporosis in humans were identified with two SNPs (rs4238686, rs11643303) in PIEZO1 among the 1103 conditionally independent signals (423 novel) at genome-wide significance (Supplementary file 2 Table 2 Morris et al., 2019). This evidence concerns the gene PIEZO1 and osteoporosis.