WWTR1 and infection: However, loss of Piezo1 or Piezo1/2 by Cre Adenovirus (Ad-Cre) infection of the Piezo1f/f or Piezo1f/f; Piezo2f/f BMSCs (Figure 6—figure supplement 1a), respectively, led to reduced osteoblast differentiation and reduced Yap1/Wwtr1 and Wnt/Ctnnb1 signaling activities (Figure 6e, Figure 6—source data 1).