Notably, NLRC3, NLRP6 and NLRP12 are implicated in the suppression of the inflammatory response, and deficiency of these proteins can confer resistance to infection in vivo (Anand et al., 2012; Zaki, Man, Vogel, Lamkanfi, & Kanneganti, 2014; Zhang et al., 2014). Here, NLRP6 is linked to infection.