TNFSF11 and osteoporosis: Angelica sinensis (AS; Dang Gui), a traditional Chinese medicine, has long been used for the treatment of bone diseases including osteoporosis and osteonecrosis.1, 2, 3 In traditional Chinese medicine, AS is considered to increase bone formation and promote fracture healing.4 In addition, it reportedly suppresses RANKL‐induced osteoclastogenesis,5, 6 osteoporosis7 and osteonecrosis of the femoral head.1 However, the active component and mechanisms underlying the benefits of AS are unclear.