An association between HbA1c and 18F-NaF uptake, had been observed in healthy controls.18 In patients with diabetes, high HbA1c is known to be associated with osteocalcin, which supports the concept of vascular calcification in patients with diabetes.19 Blomberg et al18 investigated 18F-NaF uptake in the coronary arteries of 89 healthy adults. This evidence concerns the gene BGLAP and diabetes mellitus.