MORC3 and myositis disease: Autoantibodies against anti-SAE1, anti-TIF1-γ and anti-NXP2 are associated with an increased risk of cancer in adult patients with IIM, whereas in some cases production of anti-HMGCR, anti-Jo-1 and anti-PL-12 autoantibodies may also be driven by malignancy.36 In consequence, it is recommended to always follow-up any myositis diagnosis in adults by tumour screening.