TGFB1 and systemic sclerosis: The most powerful profibrotic molecule known in humans is TGFβ; this molecule has been in the epicentre of SSc pathogenesis for decades.29 The first attempt to target TGFβ in SSc with a monoclonal antibody was unsuccessful.30 The disappointing results of that study led to an abandonment of anti-TGF therapies for many years.