In blood cellular subsets, both IL 12p35 and EBV-induced gene protein 3 (EBI3) mRNAs were detected only in B cells, with a trend toward a lower level among patients with pSS.2 Nilsson et al. in a study of 20 never-smoking pSS patients showed an increase in BAFF, IL-6 and IL-8 in induced sputum suggesting an ongoing inflammatory disease process in the airways in pSS patients.3 This evidence concerns the gene IL6 and peeling skin syndrome.