Double seropositivity of anti-Ro/SS-A and La/SS-B along with USFR were independent predictive factors for structural damage of the salivary glands.24 Mossel et al. suggested that examination of parotid and submandibular glands on one side was sufficient to predict classification of pSS patients according to ACR/EULAR criteria. This evidence concerns the gene CALR and peeling skin syndrome.