LEF1 and peeling skin syndrome: These data reveal the potential importance of RORα in controlling the lymphocytic invasion in the salivary glands and suggest that RORα may be a druggable target for treating pSS in the future.17 In another study, Shah et al. determined the expression of matrix metalloproteinase 9 (MMP9) and its putative transcription factors ETS1 and LEF1, in labial salivary glands of pSS patients.