IL33 and synovial sarcoma: Another cytokine of the IL-1 family shown to be raised in both serum and salivary gland biopsies of SS patients is IL-33, acting synergistically with IL-12 and IL-23 for the induction of IFNγ secretion by natural killer (NK) and NKT cells.1 IL-12/IL35 balance may also represent a part of the pathogenetic cascade in SS.2 Serum IL-35 levels have been associated with low disease activity in contrast with serum IL-12p70 levels which were associated with more active disease.