Type I IFN induced gene expression was found to be negatively correlated with INF-2ab induced phosphorylation of STAT3 S727 in T cells and positively with pSTAT1 Y701 in B cells, thus indicating a direct involvement of both pathways in SS pathogenesis.7 IFN-inducible protein 16 (IFI16) is an innate immune sensor that forms filamentous oligomers when activated by double-stranded DNA (dsDNA). The gene discussed is IFI16; the disease is synovial sarcoma.