DILS is a clinicopathologic entity associated with untreated or poorly controlled HIV infection, described first by Solal-Celigny et al. in 1985.32 It is now considered a rare syndrome that develops in certain HIV patients who respond to infection by CD8+ lymphocytosis, with CD8 positive T-lymphocytes infiltrating various organs, especially the salivary glands. Here, CD8A is linked to infection.