APOH and parasitic infectious disease: In these patients, APLAs display specificity for a neoepitope comprising of a complex between the beta2-GPI, a lipid-binding coagulation inhibitor, and cellular membrane phospholipids, thus having a direct role in thrombosis.71 Many viral, bacterial and parasitic infections are associated with temporary development of non-clinically significant anticardiolipin antibodies (aCLs).72 These aCLs are not specific for β2GPI, but are directed against cellular membrane lipids, so they display no thrombotic potential.72