ALOX5AP and systemic sclerosis: The rs10507391 polymorphism (T/A) of arachidonate 5-lipoxygenase activating protein (ALOX5AP) was identified in the EUSTAR cohort to predict the risk of SSc (odds ratio [OR] 1.27 [95% CI 1.07, 1.50], P < 0.05 vs controls) as well as that of ILD in SSc (OR 1.45 [95% CI 1.17, 1.79], P < 0.05 vs SSc patients without interstitial lung disease).18 A whole exome sequencing of 32 patients found BANK1 and TERT to be over-expressed.