Our results clearly demonstrate the well-recognized dominance of anti-Topo I (Scl-70) autoAbs (62%in dcSSc), and that of anti-CEN (46% in lcSSc) autoAbs in SSc patients,9,11 including those from Greece.6 Anti-Ro52 Abs remain the third most common autoAb in patients with SSc, being present in more than a fifth of patients affected with this disease.6,25 All other autoantibodies, excluding anti-RNA pol III abs which are present in approx. 13% of the patients, are infrequently found. Here, TRIM21 is linked to systemic sclerosis.