In respect to anti-Ro52 Abs, an increasing number of recent studies reports a high frequency of these autoAbs in SSc, but their clinical relevance remains uncertain, as most studies fail to identify clinical usefulness attained by this autoAb.25,32,33 Whether their appearance is an epiphenomenon or pathogenically relevant remains a matter of debate and the topic of intense investigation.34 Here, TRIM21 is linked to systemic sclerosis.