We confirmed the previously noted association of anti-Topo I Ab positivity with ILD (p<0.001), and at the other end, the negative association of anti-CENP Abs with ILD.8,35 The fact that anti-Topo I Abs are twice as high in male than in female SSc patients (a feature also seen for anti-RNA pol III and anti-NOR90 abs) is of interest and necessitates further investigation.22 The anti-NOR90 Abs, despite its low frequency, was also associated with ILD, and this should not be ignored. This evidence concerns the gene UBTF and interstitial lung disease.