Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by venous, arterial, and/or small vessel thrombosis, pregnancy morbidity, and elevated levels of antiphospholipid antibodies (aPL), namely lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), and/or anti-beta2-glycoprotein I antibodies.1 Any combination of thrombotic events is possible at variable intervals, and the syndrome can be either primary (PAPS) or associated with an underlying condition, most commonly systemic lupus erythematosus (SLE/APS). The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.