Moreover, obesity, a well known risk factor of OA, induces the activation of NF-κB, resulting in downregulation of miR-26a expression.35 On the other hand, another target gene of miR-26a is NOS2, which encodes inducible Nitric Oxide Synthase (iNOS). The gene discussed is NOS2; the disease is obesity due to melanocortin 4 receptor deficiency.