The addition of the anti-TNF and later other biologic DMARDs, targeting specific cytokines (e.g., IL-6 and IL-1), of anti-B cell therapies (e.g., rituximab) and therapies targeting other important pathways of inflammation (e.g., abatacept) in our therapeutic armamentarium has been a true revolution which has enabled a significant proportion of our RA patients to achieve remission or at least a low disease activity state – particularly when used in a “treat-to-target” (T2T) fashion. This evidence concerns the gene TNF and rheumatoid arthritis.