Data suggest that Dkk-1 regulates several aspects of bone biology9 and fibrosis.10 More specifically, it has been shown that Dkk-1 is a master regulator of joint remodeling in animal models of arthritis shifting the balance towards new bone formation when its expression is decreased and towards joint destruction when its expression is increased.11 It has been recently shown that Dkk-1 mediated Wnt inhibition could suppress TGF-β mediated fibrosis.10 The gene discussed is DKK1; the disease is Arthritis.