CRP and fibromyalgia: Lingering pain despite a good clinical response was strongly associated with functional impairment and disability at baseline,116 fibromyalgia,137 high baseline pain, and low inflammation as evidenced by lower baseline levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).138 Moreover, a pain DETECT questionnaire score ≥ 19, indicating central sensitization, predicts poorer treatment outcome estimated by clinical status (DAS28-CRP).139