IL10 and systemic lupus erythematosus: In systemic lupus erythematosus (SLE), CD19+ CD24highCD38high Breg cells were not decreased but produced less IL-10 compared to healthy controls and could not inhibit Th1 cells.16In another study, CD19+ CD24highCD27+Breg cells and IL-10+CD19+Breg cells were decreased in SLE.