CD19+ CD24highCD38high transitional Bregs and CD19+ CD24highCD27+ memory Breg cells were decreased and impaired in their production of IL-10, particularly in SSc-associated interstitial lung disease.47There was a decrease in STAT3 and p38MAPK signaling in B cells.47Interestingly, Breg cells showed an inverse correlation with disease-specific autoantibodies, anti-topoisomerase I and anticentromere antibodies.48 This evidence concerns the gene CD19 and interstitial lung disease.