In mice models of SLE, IL-10+Breg cells appear to have a protective role.16,32,33For example, CD5+CD1dhigh Breg cells from wild-type mice transferred to CD5+CD1dhigh Breg cells-deficient mice with SLE, significantly improved the survival of these mice.32In addition, administration of IL-35 to MRL/lpr mice improved clinical, laboratory, and pathological lupus nephritis, and lupus disease activity, and increased IL-10+Breg cells.34 This evidence concerns the gene CD5 and systemic lupus erythematosus.