Inhibitory oligonucleotides whose guanine moiety has been modified have been found to inhibit production of Type I IFNs by human pDCs as well as pDCs from MRL/lpr mice model of lupus which were stimulated via TLR7 and TLR9 agonists,38 identifying another potential therapeutic route in lupus. This evidence concerns the gene TLR7 and systemic lupus erythematosus.