In order to explore the associations between common SCN1A, SCN2A, and UGT2B7 gene polymorphisms, alone or in combination, with VPA responsiveness in epilepsy among 114 Chinese Han patients, we carried out a pharmacogenomics association analysis to identify whether genetic polymorphisms were correlated with VPA responses using a total of 31 SNPs in the three candidate genes. This evidence concerns the gene UGT2B7 and epilepsy.