TNF and atherosclerosis: After the exposure of Tanshinone IIA to atherosclerosis model which is established by THP-1-derived macrophages treated with ox-LDL, the expression of IL-1β, IL6, and TNF-α was decreased compared to the untreated group, and a further study revealed that Tanshinone IIA may decrease the inflammatory response by mediating miR-130b and WNT5A [47].