EGFR and neoplasm: Moreover, EMT is involved in all types of signaling pathways (e.g., NF-kB, EGFR–ERK, BMP, Wnt/β-catenin, Akt/GSK-3b/Snail, EGF/EGFR, p53/TIGAR and SCO2 pathways), which are regulated by the zinc-finger family of transcription factors, including Snail, Slug, and Twist, which contribute to tumor metastasis by promoting EMT in cervical carcinoma (Qureshi et al., 2015).